EmbryoGlue®

EmbryoGlue®

EmbryoGlue® - for increased take-home baby rate

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EmbryoGlue® increases take-home baby rate
A prospective, randomised study presented at ESHRE 2011 showed a significant increase in take home baby rate when using EmbryoGlue® for transfer, compared to the control group.

The take-home baby rate for embryo transfer on day 5 was 63.4% using EmbryoGlue compared to 52.2% in the control group1.

EmbryoGlue® increases clinical pregnancy rates
The independent research network Cochrane Collaboration has published a meta analysis 2 including 13 randomized, controlled, prospective studies on hyaluronan as an adherence compound in embryo transfers. The analysis showed that "A clear positive effect of having hyaluronic acid in the embryo transfer medium was identified overall and even for embryos that had been grown in hyaluronic acid containing media up until transfer", meaning that EmbryoGlue® has a positive effect on pregnancy rates when used for embryo transfer.

The same study showed that the use of EmbryoGlue showed no adverse effects.

 

High concentration of hyaluronan increases pregnancy rates

EmbryoGlue® is the only available transfer medium containing a high concentration of hyaluronan. When EmbryoGlue® was used for transfer the clinical pregnancy rate was significantely increased from 41% to 50% 2 compared to when a conventional culture medium with low or no hyaluronan was used.

Graph from Cochrane analysis

How does is work?

EmbryoGlue® contains all nutrients and energy sources needed for an optimal embryo development. And, most importantly, the medium contains a high concentration of implantation promoting hyaluronan Hyaluronan is the major glycosaminoglycan present in the follicular, oviductal and uterine fluids3,4,5. The physiological concentrations in these fluids provide high viscosity environments in the oviduct and uterus 6. The synthesis of hyaluronan increases dramatically on the day upon which implantation is initiated and it decreases to near basal levels by the next day, indicating its importance for the implantation event. Other types of glycosaminoglycans do not show an elevated synthesis at the time of implantation 7,8.

Hyaluronan makes the difference

EmbryoGlue® has the basic composition of a rich blastocyst culture medium and contains a high concentration of hyaluronan and recombinant human albumin. It can be used for transfer of all embryo developmental stages, including embryos after assisted hatching, biopsy and cryopreservation. The use of EmbryoGlue® for embryo transfer will increase the clinical pregnancy rate and following delivery rate and there are many studies to show it.

Safe implantation

EmbryoGlue® contains recombinant human albumin for avoiding the risks related to blood derived

  1. B Balaban et al. (2011) Oral presentation 0-060, ESHRE 2011.
  2. Bontekoe S, et al. Adherence compounds in embryo transfer media for assisted reproductive technologies. Cochrane Database Syst Rev. 2010;7:CD007421.
  3. Lee and Ax. (1984). J Dairy Science 67.
  4. Suchanek et al. (1994). Fert Steril 62.
  5. Rodiguez-Martinez et al. (1998). In Gametes: Development and Function, Serono symposia.
  6. Kano et al. (1998). Biol of Reprod 58.
  7. Carson et al. (1987). Dev Biol 120.
  8. Zorn et al ( 1995). Cell Mol Biol 41.
Product description
Type Description
PurposeFor embryo transfer.
DescriptionBicarbonate buffered medium containing Hyaluronan and Recombinant Human Albumin.
ApplicationFor use after pre-equilibration at +37ºC and 6 % CO2.
StorageStore dark at +2 to +8ºC.