Vitrolife MEA Laboratory Manager, Brett Glazar, talks about how to improve the embryo culture system by avoiding reprotoxicity.

Many factors affect clinical success

Stimulation regimes, transfer techniques and the culture environment with temperature, pH and oxygen tension are all factors that have a direct effect on embryo development in culture. All variables need to be taken into account in order to optimize pregnancy rates.

Stress reduces viability

Embryos are put to stress just by being in an in-vitro system. This stress is cumulative and can have negative effects on embryo viability.

The importance of quality tested disposables

Plastic disposables are used throughout the IVF process, but only a small percentage of them are suitably tested. When plastic disposables are insufficiently quality controlled, they can contain components that are toxic to gametes and embryos. This phenomenon can be referred to as reprotoxicity.

Reprotoxicity can be minimized

Reprotoxicity is defined as a negative influence on the physiology and viability of human gametes and embryos. Reprotoxicity can result in reduced gamete and embryo viability with a subsequent reduction in implantation rate or ongoing pregnancy rates. By exclusively using media and contact supplies that have been accurately tested, reprotoxizity can be minimized.

Vitrolife MEA can detect sup-optimal conditions

Vitrolife has developed the most sensitive MEA protocols. These assays are capable of detecting toxic and sub-optimal raw materials, media, and contact materials. The MEA from Vitrolife is sensitive enough to identify subtle problems that will also lead to impaired human embryo development.