Basile N, Vime P, Florensa M, Aparicio Ruiz B, García Velasco JA, Remohí J, Meseguer M. (2015) “The use of morphokinetics as a predictor of  implantation: a multicentric study to define and validate an algorithm for embryo selection” Hum Reprod. 2015 Feb;30(2):276-83 http://humrep.oxfordjournals.org/content/30/2/276.abstract

Bodri D, Kato R, Kondo M, Hosomi N, Katsumata Y, Kawachiya S, Matsumoto T. (2015) “Time-lapse monitoring of zona pellucida-free embryos obtained through in vitro fertilization: a retrospective case series” Fertil Steril. 2015 Mar 12. pii: S0015-0282(15)00138-7

Bronet F, Nogales MC, Martínez E, Ariza M, Rubio C, García-Velasco JA, Meseguer M. (2015) ”Is there a relationship between time-lapse parameters and embryo sex?” Fertil Steril. 2015 Feb;103(2):396-401.e2

Cetinkaya M, Pirkevi C, Yelke H, Colakoglu YK, Atayurt Z, Kahraman S. (2015) “Relative kinetic expressions defining cleavage synchronicity are better predictors of blastocyst formation and quality than absolute time points” J Assist Reprod Genet. 2015 Jan;32(1):27-35

Chamayou S, Romano S, Alecci C, Storaci G, Ragolia C, Palagiano A, Guglielmino A. (2015) “Oocyte vitrification modifies nucleolar remodeling and zygote kinetics-a sibling study” J Assist Reprod Genet. 2015 Apr;32(4):581-6

Chawla M, Fakih M, Shunnar A, Bayram A, Hellani A, Perumal V, Divakaran J, Budak E. (2015) “Morphokinetic analysis of cleavage stage embryos and its relationship to aneuploidy in a retrospective time-lapse imaging study” J Assist Reprod Genet. 2015 Jan;32(1):69-75 http://link.springer.com/article/10.1007%2Fs10815-014-0372-3

Fréour T, Le Fleuter N, Lammers J, Splingart C, Reignier A, Barrière P. (2015) “External validation of a time-lapse prediction model” Fertil Steril. 2015 Apr;103(4):917-22

Milewski R, Kuć P, Kuczyńska A, Stankiewicz B, Łukaszuk K, Kuczyński W. (2015) “A predictive model for blastocyst formation based on morphokinetic parameters in time-lapse monitoring of embryo development” J Assist Reprod Genet. 2015 Apr;32(4):571-9

Mölder A, Drury S, Costen N, Hartshorne GM, Czanner S. (2015) “Semiautomated analysis of embryoscope images: Using localized variance of image intensity to detect embryo developmental stages” Cytometry A. 2015 Feb;87(2):119-28 http://onlinelibrary.wiley.com/doi/10.1002/cyto.a.22611/abstract

Park H, Bergh C, Selleskog U, Thurin-Kjellberg A, Lundin K. (2015) “No benefit of culturing embryos in a closed system compared with a conventional incubator in terms of number of good quality embryos: results from an RCT” Hum Reprod. 2015 Feb;30(2):268-75 http://humrep.oxfordjournals.org/content/30/2/268.abstract

Stensen MH, Tanbo TG, Storeng R, Åbyholm T, Fedorcsak P. (2015) ”Fragmentation of human cleavage-stage embryos is related to the progression through meiotic and mitotic cell cycles” Fertil Steril. 2015 Feb;103(2):374-81.e4



Aguilar J, Motato Y, Escribá MJ, Ojeda M, Muñoz E, Meseguer M. (2014) “The human first cell cycle: impact on implantation” Reprod Biomed Online 28(4):475-484 http://www.rbmojournal.com/article/S1472-6483(13)00631-7/abstract

Basile N., Nogales, M.C., Bronet, F., Florensa, M., Riqueiros, M., Rodrigo, L., Garcia-Velasco, J., Meseguer, M. (2014) ”Increasing the probability of selecting chromosomally normal embryos by time-lapse morphokinetic analysis” Fertil Steril 2014; 101(3), 699-704

Campbell A, Fishel S, Laegdsmand M. (2014) “Aneuploidy is a key causal factor of delays in blastulation: author response to ‘A cautionary note against aneuploidy risk assessment using time-lapse imaging”  Reprod Biomed Online 28(3): 279-83

Desai N, Ploskonka S,  Goodman LR, Austin C, Goldberg J, Falcone T (2014) “Analysis of embryo morphokinetics, multinucleation and cleavage anomalies using continuous time-lapse monitoring in blastocyst transfer cycles” Reprod Biol Endocrinol 12:54 doi: 10.1186/1477-7827-12-54

Ergin EG, Çalişkan E, Yalçinkaya E, Öztel Z, Çökelez K, Özay A, Özörnek HM (2014) ”Frequency of embryo multinucleation detected by time-lapse system and its impact on pregnancy outcome” Fertil Steril 102(4): 1029–1033

Joergensen MW, Agerholm I, Hindkjaer J, Bolund L, Sunde L, Ingerslev HJ, Kirkegaard K. (2014) ”Altered cleavage patterns in human tripronuclear embryos and their association to fertilization method: A time-lapse study” J Assist Reprod Genet 31(4): 435-42

Lammers J, Splingart C, Barriére P, Freour T. (2014) “Morphokinetic parameters of ICSI tripronucleated embryos observed using time lapse” Reprod Biomed Online 28(5): 658-60

Li R, Pedersen KS, Liu Y, Pedersen HS, Lægdsmand M, Rickelt LF, Kühl M, Callesen H (2014) ”Effect of red light on the development and quality of mammalian embryos” J Assist Reprod Genet 31(7): 795-801

Liu Y, Chapple V, Roberts P, Ali J, Matson P. (2014) “Time-lapse videography of human oocytes following intracytoplasmic sperm injection: events up to the first cleavage division” Reprod Biol. 2014 Dec;14(4):249-56

Liu Y, Chapple V, Roberts P, Matson P (2014) “Prevalence, consequence, and significance of reverse cleavage by human embryos viewed with the use of the Embryoscope time-lapse video system”  Fertil Steril doi: 10.1016/j.fertnstert.2014.07.1235

Kirkegaard K, Campbell A, Agerholm I, Bentin-Ley U, Gabrielsen A, Kirk J, Sayed S, Ingerslev HJ (2014) “Limitations of a time-lapse blastocyst prediction model: a large multicentre outcome analysis” Reprod Biomed Online 29(2):156-158

Morbeck, D, Paczkowski M, Fredrickson JR, Krisher RL, Hoff HS, Baumann NA, Moyer T, Matern D (2014) “Composition of protein supplements used for human embryo culture” J Assist Reprod Genet, doi: 10.1007/s10815-014-0349-2

Morbeck DE, Krisher RL, Herrick JR, Baumann NA, Matern D, Moyer T (2014) ” Composition of commercial media used for human embryo culture” Fertil Steril 102(3): 759-766http://www.fertstert.org/article/S0015-0282(14)00506-8/abstract

Rienzi L, Capalbo A, Stoppa M, Romano S, Maggiulli R, Albricci L, Scarica C, Farcomeni A, Vajta G, Ubaldi FM (2014) “No evidence of association between blastocyst aneuploidy and morphokinetic assessment in a selected population of poor-prognosis patients: A longitudinal cohort study” Reprod Biomed Online DOI: http://dx.doi.org/10.1016/j.rbmo.2014.09.012

Rubio I,Galán A, Larreategui Z, Ayerdi F, Bellver J, Herrero J, Meseguer M (2014) “Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope” Fertil Steril. DOI: http://dx.doi.org/10.1016/j.fertnstert.2014.07.738

Stecher A, Vanderzwalmen P, Zintz M, Wirleitner B, Schuff M, Spitzer D, Zech NH (2014) “Transfer of blastocysts with deviant morphological and morphokinetic parameters at early stages of in-vitro development: a case series” Reprod Biomed Online 28(4): 424-435

Wilken-Jensen HN, Kristensen SG, Jeppesen JV, Yding Andersen C (2014) ”Developmental competence of oocytes isolated from surplus medulla tissue in connection with cryopreservation of ovarian tissue for fertility preservation” Acta Obstet Gynecol Scand 93(1):32-7 

Wissing ML, Bjerge MR, Olesen AI, Hoest T, Mikkelsen AL. (2014) “Impact of PCOS on early embryo cleavage kinetics” Reprod Biomed Online 28(4): 508-14

Yang Z, Zhang J, Salem SA, Liu X, Kuang Y, Salem RD, Liu J (2014) “Selection of competent blastocysts for transfer by combining time-lapse monitoring and array CGH testing for patients undergoing preimplantation genetic screening: a prospective study with sibling oocytes” BMC Medical Genomics 2014, 7:38 



Basile, N., Morbeck, D., Garcia-Velasco, J., Bronet, F. and Meseguer, M (2013) “Type of culture media does not affect embryo kinetics: a time-lapse analysis of sibling oocytes” Hum Reprod 28(3): 634-641


Bellver, J., Mifsud, A., Grau, N., Pritera, L. and Meseguer, M. (2013) “Similar morphokinetic patterns in embryos derived from obese and normoweight infertile women: a time-lapse study” Hum Reprod 28(3): 794-800

Campbell, A., Fishel, S., Bowman, N., Duffy, S., Sedler, M. and Hickman, C.F.L. (2013) “Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics” Reprod Biomed Online 26(5): 477-485

Campbell, A., Fishel, S., Bowman, N., Duffy, S., Sedler, M., Thornton, S. (2013) “Retrospective analysis of outcomes after IVF using an aneuploidy risk model derived from time-lapse imaging without PGS” Reprod Biomed Online 27(2): 140-146

Chamayou, S., Patrizio, P., Storaci, G., Tomaselli, V., Alecci, C., Ragolia, C., Crescenzo, C., and Guglielmino, A. (2013) “The use of morphokinetic parameters to select all embryos with full capacity to implant” J Assist Reprod Genet 30(5): 703-710

Fréour T, Dessolle L, Lammers J, Lattes S, Barrière P. (2013) “Comparison of embryo morphokinetics after in vitro fertilization-intracytoplasmic sperm injection in smoking and nonsmoking women” Fert Steril 99(7): 1944-1950

Herrero, J. and Meseguer, M. (2013) ”Selection of high potential embryos using time-lapse imaging: the era of morphokinetics” Fertil Steril 99(4): 1030-1034

Herrero, J., Tejera, A., Albert, C., Vidal, C., de Los Santos, M. J., M. Meseguer (2013) “A time to look back: analysis of morphokinetic characteristics of human embryo development” Fertil Steril doi: 10.1016/j.fertnstert.2013.08.033

Kirkegaard, K., Hindkjaer, J. J. and Ingerslev, H. J. (2013) “Hatching of in vitro fertilized human embryos is influenced by fertilization method”, Fertil Steril. doi: 10.1016/j.fertnstert.2013.07.005

Kirkegaard K, Kesmodel US, Hindkjær JJ, Ingerslev HJ (2013) “Time-lapse parameters as predictors of blastocyst development and pregnancy outcome in embryos from good prognosis patients: a prospective cohort study” Hum. Reprod. 28(10):2643-51

Sundvall, L., Ingerslev, H. J., Breth Knudsen, U., Kirkegaard, K. (2013) “Inter- and intra-observer variability of time-lapse annotations” Hum Reprod doi: 10.1093/humrep/det366

Wolff, H.S., Fredrickson, J.R., Walker, D.L., Morbeck, D.E. (2013) “Advances in quality control: mouse embryo morphokinetics are sensitive markers of in vitro stress” Hum. Reprod. 28(7): 1776-1782


Azzarello, A., Hoest, T. and Mikkelsen, A.L. (2012) “The impact of pronuclei morphology and dynamicity on live birth outcome after time-lapse culture” Hum Reprod 27(9): 2649-2657

Basile, N. and Meseguer, M. (2012) “Time-lapse technology: evaluation of embryo quality and new markers for embryo selection” Expert Rev Obstet Gynecol 7(2): 175-190

Canto, M.B., Coticchio, G., Renzini, M.M., Ponti, E., Novara, P.V., Brambillasca, F., Comi, R. and Fadini, R. (2012) “Cleavage kinetics analysis of human embryos predicts development to blastocyst and implantation” Reprod Biomed Online 25(5):474-80

Ciray, N.H., Aksoy, T., Goktas, C., Ozturk, B. and Bahceci, M. (2012) “Time-lapse evaluation of human embryo development in single versus sequential culture media – a sibling oocyte study” J Assist Reprod Genet 29(9): 891-900

Cruz, M., Garrido, N., Herrero, J., Pérez-Cano, I., Muñoz, M. and Meseguer, M. (2012) “Timing of cell divisions in human cleavage-stage embryos correlates with blastocyst formation and quality”. Reprod Biomed Online 28(7): 569-573 

Escrich, L., Grau, N., de los Santos, M.J., Romero, j.L., Pellicer, A. and Escribá, M.J. (2012) “The dynamics of in vitro maturation of germinal vesicle oocytes” Fertil Steril 98(5): 1147-1151

Kirkegaard K., Agerholm I.E. and Ingerslev H.J. (2012) ”Time-lapse monitoring as a tool for clinical embryo assessment” Hum Reprod 27(5): 1277-1285

Kirkegaard K., Hindkjaer J. J., Grøndahl, M. L., Kesmodel, U. S. and Ingerslev H.J. (2012) ”A randomized clinical trial comparing embryo culture in a conventional incubator with a time-lapse incubator” J Assist Reprod Genet 29(6): 565-572

Kirkegaard, K., Hindkjaer, J.J., Ingerslev, H.J. (2012) ”Effect of oxygen concentration on human embryo development evaluated by time-lapse monitoring” Fertil Steril  99(3): 738-744

Meseguer, M., Kruhne, U. and Laursen, S. (2012) “Full in vitro fertilization laboratory mechanization: toward robotic assisted reproduction?” Fertil Steril 97(6): 1277-1286

Meseguer, M., Rubio, I. Cruz, M., Basile, N., Marcos, J. and Requena, A. (2012) “Embryo incubation and selection in a time-lapse monitoring system improves pregnancy outcome in comparison with a standard incubator; a retrospective cohort study” Fert Steril 98(6): 1481-1489

Muños, M., Cruz, M., Humaidan, P., Garrido, N., Pérez-Cano, I. and Meseguer, M. (2012) “Dose of recombinant FSH and estradiol levels on the hCG day affect embryo developmental kinetics” Reprod Biomed Online 25(4): 382-389

Rubio, I., Herrero, J. and Meseguer, M. (2012) “A review of recent trials selecting viable embryos for transfer – comprehensive time-lapse imaging analysis” Eur J Obstet Gynaecol Reprod Biol 7(2): 66-70

Rubio, I., Kuhlmann, R., Agerholm, I., Kirk, J., Herrero, J., Escriba, M.J., Bellver, J. and Meseguer, M. (2012) “Limited implantation success of direct-cleaved human zygotes: A time-lapse study” Fert Steril 98(6): 1458-1463


Cruz, M., Gadea, B., Garrido, N., Pedersen, K.S., Martínez, M., Pérez-Cano, I., Muñoz, M. and Meseguer, M. (2011) “Embryo quality, blastocyst and ongoing pregnancy rates in oocyte donation patients whose embryos were monitored by time-lapse imaging” J Assist Reprod Genet 28(7): 569-573

Kirkegaard, K., Hindkjaer, J. J., and Ingerslev, H.J. (2011) ”Human embryonic development after blastomere removal: a time-lapse analysis” Hum Reprod 27(1): 97-105

Meseguer, M., Tejera, A., Hilligsøe, K.M., Ramsing, N.B. and Remohí, J. (2011) “The use of morphokinetics as a predictor of embryo implantation” Human Reprod 26(10): 2658-2671


Montag, M., Liebenthron, J. and Köster, M. (2011) “Which morphological scoring system is relevant in human embryo development” Placenta 32(3): 252-256


Lopes, A.S., Lane, M. and Thompson, J.G. (2010) “Oxygen consumption and ROS production are increased at the time of fertilization and cell cleavage in bovine zygotes” Hum Reprod, 25 (11): 2762–2773