2015 has begun with a significant milestone for the EmbryoScope community. We are proud to announce that EmbryoScope number 500 has been installed. It is also a key milestone as this 500th installation is EmbryoScope number 10 at the clinic in question: Weill Medical College of Cornell University, Center for Reproductive Medicine. Because of the numerous benefits of the EmbryoScope time-lapse system, the center has implemented 100% time-lapse embryo incubation and monitoring of embryos in EmbryoScope incubators.
Improved culture conditions
One of the immediate benefits of the time-lapse system compared to standard incubation is better culture conditions. Dr. Nikica Zaninovic, Embryology Laboratory Director and Assistant Professor, says this was the reason behind moving towards using 100 % time-lapse in the center’s laboratory:
“After extensive testing of sibling oocytes between EmbryoScope (E) vs. standard incubator, our results showed superior embryo development in E compared to standard incubator. This was especially evident when reduced oxygen culture was used,” he says and adds:
“Besides better culture conditions, we were able to observe abnormal embryo development using time-lapse and exclude abnormal embryos from embryo transfers.”
Better embryo selection
The improved culture conditions have not only lead to better embryo development. The center has seen an even more significant benefit by using EmbryoScope for all their patients:
“Better culture conditions with reduced oxygen produce healthier embryos, more blastocysts and increase in clinical outcome evident by the increase in clinical pregnancy rate and implantation rate,” Dr. Zaninovic determines and elaborates:
“Embryos can be observed for their normal and abnormal development which is used for better embryo selection for transfers. We increase our blastocyst freezing rate per embryo and per cycle using EmbryoScope,” he states.
In fact, time-lapse information and clues to abnormal embryo development have had an essential and very positive effect on embryo selection at the center:
“Deselecting abnormally dividing embryos (~20% of all embryos) increase our ability to select embryos for blastocyst culture and chose one with the highest implantation potential,” Dr. Zaninovic tells us.
The center is now applying their own embryo selection models (developed using more than 20,000 transferred embryos) to increase clinical outcome. A prospective study is underway.
Improvement in clinical results
Since the first EmbryoScope time-lapse system was installed at the center in 2011, Dr. Zaninovic and his team have experienced several improvements in clinical results:
- An overall increase in clinical pregnancies, implantation and life birth rate.
- Improvement mostly evident in patients less than 40 years old.
- Increase in blastocyst ET rate with the increase of SET without lowering implantation rate.
These results speak for themselves. We are very proud to have our EmbryoScope number 500 in the world installed at this pioneering and innovative center.