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vitROShield protects your embryos in culture from pH induced stress, free oxygen radicals, infections and cryodamage |
| vitROShield is the combination of hyaluronan, gentamicin and the antioxidant lipoate in the culture system. |
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Lipoate is one of the most potent antioxidants known; it protects against reactive oxygen species present in the culture environment. |
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Gentamicin offers broad spectrum protection against bacterial agents. |
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Hyaluronan enhances embryo viability and cryosurvivability. |
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pH close to the intra-cellular level protects from perturbations in embryo development. |
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What is oxidative stress? |
Oxidative stress is caused by free reactive oxygen species, so called ROS.
There may be multiple sources of ROS in an IVF setting. One possible source of ROS is visible light. Light is able to induce ROS production and cellular damage such as oxidation of bases and DNA strand breaks.
A major contributor to the production of ROS is also the concentration of oxygen itself.
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IVF culture is constantly exposed to free oxygen radicals and pollutants originating from light, air and environment.
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How can oxidative stress be overcome in ART? |
Oxidative stress can be overcome by reducing the generation of ROS directly. Alternatively, one can increase the amounts of antioxidants available.
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Lipoat - the antioxidant of antioxidants |
Lipoate is a potent antioxidant. It is thought to be synthesised in the mitochondria of animals, bacteria and plants. It contains soluble properties allowing interactions in both aqueous and lipid phases, a unique feature among antioxidants.
Furthermore, lipoate is capable of regenerating other antioxidants including glutathione. For this reason it has been called “the antioxidant of antioxidants”.5
Lipoat is one of the companents in vitROShield and is present in the G5 Series™.
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