Successful novel blastocyst vitrification and embryo transfer strategy

At CFAS 2012, Ottawa Fertility Center presented a new strategy for obtaining high pregnancy rates in their elective single embryo transfer (eSET) program. The aim of the study was to evaluate the new closed vitrification device Rapid-i™ and the effectiveness of combining the transfer of a single fresh blastocyst with a single vitrified blastocyst.

Evaluation of the new closed vitrification system Rapid-i

The results of the vitrification cycles showed a high clinical pregnancy rate (CPR) of 48.6%, similar to the results of fresh blastocyst eSET, 53.6%, and a survival rate of 88%. However, the high multiple pregnancy rate (MPR) when more than one blastocyst was transferred was a reason for concern. The Ottawa Fertility Centre therefore decided to determine the effectiveness of combining a fresh single elective blastocyst transfer with a single (S-FET) compared to a double (D-FET) vitrified embryo transfer.

New transfer strategy

31 patients that had a fresh eSET returned for an additional transfer (FET) of a vitrified/warmed blastocyst. 17 of the 31 patients had a single frozen embryo transfer (S-FET), and 14 had a double frozen embryo transfer (D-FET).

Graph vitrification Ottawa ASRM 2012 

The clinic concluded that ”transferring one fresh and one vitrified blastocyst at a time can lead to very high cumulative pregnancy rates while maintaining very low multiple pregnancy rates”.

REF:

A.P. Tartia et al. Poster presentation. CFAS 2012.