Rapid-i™ Vitrification System
For time-efficient, easy and successful vitrification.
- Description: Vitrification device
- Description: Vitrification device
- Description: Vitrification device
- Description: Vitrification device
- Description: Vitrification device
- Description: Box for liquid nitrogen, used with Rapid-i™ accessories.
- Purpose: Hard shell box for working with Rapid-i™ outside LAF-hoods.
- Application: For use with liquid nitrogen, Rapid-i Kit and Rapid-i accessories.
Disclaimer: Replaces SmartBox™ 14408 and SmartBox™ Mini 14418.
- Description: Sealer PS-202
- Purpose: Ultrasonic sealer for sealing Rapid-i Kits.
- Application: For use with Rapid-i Kits after validation.
- Description: Sealer PS-202
- Purpose: Ultrasonic sealer for sealing Rapid-i Kits.
- Application: For use with Rapid-i Kits after validation.
- Description: Metal cane for holding goblets used in cryopreservation
- Purpose: For storage of Rapid-i™ Kit in cryotank, holds 1 goblet.
- Application: For use with liquid nitrogen dewar and holder.
- Description: Plastic goblet for holding straws used in cryopreservation.
- Purpose: To hold Rapid-i™ Kit in cryopreservation storage.
- Application: For use with liquid nitrogen dewar and holder.
- Description: Cutter
- Purpose: For opening of Rapid-i straw.
- Application: For use with Rapid-i Kits in opening and retrieval.
- Description: Forceps
- Purpose: For retrieval of Rapid-i stick after opening.
- Application: For use with Rapid-i Kits in opening and retrieval.
Discover the Rapid-i™ Vitrification System – for safe, easy and successful vitrification
The Rapid-i Vitrification System has long been the natural choice for embryologists looking to optimise their vitrification workflow. The method, media, device, and accessories are all you need to simplify your workflow – from vitrification and storage to warming of oocytes and embryos.
Aseptic and closed system
Rapid-i Vitrification System is an aseptic and closed system removing the concerns regarding potential contamination from liquid nitrogen during transport and storage.
As the oocytes or embryos do not come in direct contact with liquid nitrogen, there is no need to sterilise liquid nitrogen. After vitrification, the RapidStraw is ultrasonically sealed providing safe storage.
Easy to use
The Rapid-i Kit is renowned for its simple handling. It supports a smooth workflow and eliminates risks of contamination during vitrification, storage and transport.
Oocytes or embryos are held by surface tension in a standardised volume. This simplifies loading and reduces variability between operators. It is easy to see when the right volume of medium has been applied.
Colour coded straws
To simplify identification and cryostorage management, the RapidStraws are available with five different colour codes; blue, green, red, yellow and transparent.
What is the one thing you wish every embryologist would know about vitrification?
Embarking on a journey into the intricate world of cryopreservation, we sought wisdom from Hubert Joris, Media Research Manager at Vitrolife Group. Hubert shares his insights into the evolution of cryopreservation over the last decades.
Media for every need
We provide media for vitrification and warming of all stages, from oocytes to blastocysts. Our vitrification media gives maximum support. It is based on the G-Series with amino acids and energy substrates that support embryo metabolism.
RapidVit™ & RapidWarm™ Blast
Media for vitrification and warming of blastocyst stage embryos.
Learn more
RapidVit™ & RapidWarm™ Cleave
Media for vitrification and warming of cleavage stage embryos.
Learn moreRapid-i accessories
SmartBox 3™
Box for liquid nitrogen, used with
Rapid-i tools.
Rapid-i™ Sealer
Ultrasonic sealer for sealing Rapid-i Kits.
Rapid-i™ Cutter
For opening of Rapid-i straw.
Rapid-i™ Forceps
For retrieval of Rapid-i stick after opening.
Rapid-i™ CryoCane
Aluminum cryocane for storage of Rapid-i Kit in cryotank.
Rapid-i™ Goblet
Plastic goblet for holding straws used in cryopreservation.
SmartBox 3 to keep you well organised and safe
The SmartBox 3 is designed to keep you safe and to improve your working comfort in the lab during vitrification. New product features provide a more seamless, predictable, and repeatable workflow.
Learn more about SmartBox 3
How Rapid-i Vitrification System impacts the daily work at Chu de Nantes.
- Professor Thomas Freour, Chef de service - Biologie et Médecine de la Reproduction, gynécologie médicale Responsable du centre AMP, CHU de Nates
Proven success
Numerous publications show that Rapid-i Vitrification System provides excellent outcomes after vitrification of all stages, from oocytes to blastocysts. Independent published studies show that Rapid-i Vitrification System performs equally well as open vitrification systems and provides safe storage. 1,2
"The Rapid-i Vitrification System impacts our daily workflow in a positive way. It is fast, easy to use and repeatable amongst all embryologist"
- Glenn Proctor, MHA, Director of Laboratories, Conceptions Reproductive Associates of Colorado
Rapid-i Vitrification System – Summaries of selected studies
The Rapid-i Vitrification System has long been the natural choice for embryologists looking to optimise their vitrification workflow. In this document we have gathered the strongest clinical evidence between 2010-2022. It includes 14 published papers using products from the Rapid-i Vitrification System and demonstrates the efficiency and safety of the methodology.
Download summaries
Comparison of closed vs open vitrification devices
Vitrification is used for medically assisted reproduction and fertility preservation: the goal is to ensure the maximum survival rate with the highest level of biosafety. In this blog post, we will compare closed and open carrier devices for vitrification.
Read blog post
Rapid-i Vitrification System - Tips & Tricks
This guide highlights practical tips and tricks for a successful vitrification. It contains 12 pages with text, images and illustrations explaining how to work the different steps in the process.
Download your copy nowImportant factors for
successful vitrification
Download the white paper "How to be successful with vitrification" and learn more about factors influencing high survival rates in vitrification and warming.
Download white paper
Blog: 'Is it necessary to collapse blastocysts before vitrification?'
In recent years blastocyst vitrification has become a very common embryo cryopreservation method. Our support embryologist Dr. Jakobsson is often asked about the necessity and importance of collapsing blastocysts before vitrification. In this blog post she will go through published studies on the topic and provide you with an answer.
Read blog
Vitrolife Academy online training
This course cover the background and technical details surrounding the vitrification and warming of oocytes and embryos. You will learn more about the details surrounding the Vitrolife media and devices used during vitrification and warming as well as the associated protocols. This short video will give you an introduction to the online course.
Log in or request accountEducational material
Do you need support in how to use our products? Or do you want to increase your knowledge?
Explore moreReferences
1. Desai NN, Goldberg JM, Austin C, Falcone T. The new Rapid-i carrier is an effective system for human embryo vitrification at both the blastocyst and cleavage stage. Reprod Biol Endocrinol. 2013 May 15;11:41.
2. Hashimoto S, Amo A, Hama S, Ohsumi K, Nakaoka Y, Morimoto Y. A closed system supports the developmental competence of human embryos after vitrification : Closed vitrification of human embryos. J Assist Reprod Genet. 2013 Mar;30(3):371-6.
3. Iwahata H, Hashimoto S, Inoue M, Inoue T, Ito K, Nakaoka Y, Suzuki N, Morimoto Y. Neonatal outcomes after the implantation of human embryos vitrified using a closed-system device. J Assist Reprod Genet. 2015 Apr;32(4):521-6.
4. Gook DA, Choo B, Bourne H, Lewis K, Edgar DH. Closed vitrification of human oocytes and blastocysts: outcomes from a series of clinical cases. J Assist Reprod Genet. 2016 Sep;33(9):1247-52.
5. Desai N, Ploskonka S, Goodman L, Attaran M, Goldberg JM, Austin C, Falcone T. Delayed blastulation, multinucleation, and expansion grade are independently associated with live-birth rates in frozen blastocyst transfer cycles. Fertil Steril. 2016 Nov;106(6):1370-1378.
6. Sciorio R, Thong KJ, Pickering SJ. Single blastocyst transfer (SET) and pregnancy outcome of day 5 and day 6 human blastocysts vitrified using a closed device. Cryobiology. 2018 Oct;84:40-45.
7. Sciorio R, Thong KJ, Pickering SJ. Increased pregnancy outcome after day 5 versus day 6 transfers of human vitrified-warmed blastocysts. Zygote. 2019 Oct;27(5):279-284.
8. Gunst J. et al, Data on file, 2019. Slow developing embryos undergoing compaction or cavitation on day 5 substantially contribute to live birth rates after single day 6 vitrified-warmed blastocyst transfer, P-135, 36th annual meeting of the Society for Human Reproduction and Embryology, 2020.
9. Balaban B, Isiklar A, Urman B, Gardner DK, Larman MG. Vitrification of human and mouse embryos using the Rapid-i. Fertil Steril. 2010 Sep;94(4): S115.
10. Pinasco M, Hickman T, Russell H, Rashiv B. Oocyte Vitrification Freeze/Thaw Survival Rates Using an Open Versus a Closed System. Fertil Steril. 2012 March;97(3):S18.
11. Machac S, Hubinka V, Larman M, Koudelka M. A novel method for human oocyte vitrification with a closed device using super-cooled air. Fertil Steril. 2013 Oct;100(3):S108.
12. Perez O, Tilley B, Navarrete G, Lay L, Little LM, Gada R, Chantilis S. Oocyte vitrification using a new vitrification medium and a new closed vitrification device. A sibling oocyte study. Fertil Steril. 2018 Sep;110(4):E179-E180.
13. Pujol A, Zamora MJ, Obradors A, Garcia D, Rodriguez A, Vassena R. Comparison of two different oocyte vitrification methods: a prospective, paired study on the same genetic background and stimulation protocol. Hum Reprod. 2019 Jun 4;34(6):989-997.
14. Vitrolife data-on-file 2022.
Support Documents
Documents Language
Package inserts
English
Package insert Rapid-i Kit
Document and Ref: REF 26851, version 07
Package inserts
English
Package insert SmartBox 3
Document and Ref: REF 28349, version 01
Short protocols
English
Rapid-i™ Vitrification Omni. For all stages, from oocytes to blastocysts
Document and Ref: REF 19105. Version 02. Date of issue 220923. This short protocol describes how to vitrify and warm all cell stages from oocytes to blastocysts using Rapid-i ™vitrification system and RapidVit™/Warm™ Omni.
Short protocols
English
Rapid- i™ Vitrification of oocytes
Document and Ref: REF 19129. Version 03. Date of issue 220923. This short protocol describes how to vitrify and warm oocytes using Rapid-i™ vitrification system and RapidVit™/RapidWarm™ Oocyte.
Short protocols
English
Rapid-i™ Vitrification of Cleavage stage embryos
Document and Ref: REF 19127. Version 03. Date of issue 220923. This short protocol describes how to vitrify and warm cleavage stage embryos using Rapid-i™ vitrification system and RapidVit™/RapidWarm ™ Cleave.
Short protocols
English
Rapid-i™ Vitrification System of blastocysts
Document and Ref: REF 19128. Version 03. Date of issue 220923. This short protocol describes how to vitrify and warm blastocysts using Rapid-i™ vitrification system and RapidVit™/RapidWarm™ Blast.
Scientific summaries
English
Rapid-i is an effective system for human embryo vitrification at both the blastocyst and cleavage stage
Document and Ref: In this study, Desai et al, conclude that “Rapid-i offers an excellent alternative to existing open vitrification devices for both day 3 embryos and for blastocysts” at the same time as it prevents direct contacts between embryos and liquid nitrogen.
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