EmbryoScope+ time-lapse system

Making time-lapse a standard of care.

Purpose For embryo culture & evaluation.

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16401 EmbryoScope+®
  • Description: EmbryoScope+ time-lapse incubator 110V-240V (Japan).
16402 EmbryoScope+®
  • Description: EmbryoScope+ time-lapse incubator 230V.
16460 EmbryoScope+® Barcode label printer
  • Description: Label printer for EmbryoScope+.

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Learn more about how EmbryoScope can help with your IVF treatment

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Improve IVF treatment through better embryo selection 

Time-lapse technology reduces observational time restrictions and stress to embryos during culture and assessment. With time-lapse you can enjoy undisturbed culture and continuous image acquisition and improve your selection process through a more objective analysis.

Solving the observational dilemma

The desire to observe embryos regularly in order to make accurate assessments, while minimising disturbance to avoid stressing them, has been a long-standing dilemma. Time-lapse technology solves this problem by giving you continuous observation in an undisturbed culture. Once taken, acquired images can be played as a film that can be analysed at the clinic and remotely. Without time-lapse, embryos must be taken out of the incubator to be assessed, exposing them to unnecessary stress and fluctuations.

EmbryoScope+, making time-lapse standard of care

EmbryoScope+ is designed to meet the needs of clinics wishing to implement time-lapse as a standard of care to more of their patients. 

EmbryoScope+, high capacity with a small footprint

EmbryoScope+ has more than double the patient capacity, compared to other bench-top time-lapse systems. The EmbryoScope+ can simultaneously acquire time-lapse videos from up to 15 patient dishes with up to 16 embryos each making it ideal for clinics who wish to offer time-lapse to all of their patients.

To improve workflow, the EmbryoSlide+ culture dishes are automatically registered using a special patient barcode labelling system. With the small footprint you will make efficient use of space, a valued asset in all labs and especially where space is limited. The large capacity in combination with a small footprint and efficient workflow provides optimised usage of clinic resources.

Easy patient addition workflow

A patient identification barcode system offers a flexible and efficient workflow. EmbryoScope+ automatically reads and registers entry of a new patient and re-entry of an existing patient dish.

Minimal culture disturbance

The EmbryoSlide culture dish handling port is isolated from the remainder of the  incubation chamber. This unique design ensures that culture conditions inside the  incubator are virtually undisturbed when a patient culture dish is added or removed.

Easy and efficient gas and temperature validation

An easy to access gas sampling port is positioned at the front of the EmbryoScope+. An intuitive menu guides the process of setting and validating gas and temperature set points.

Undisturbed stable incubation

EmbryoScope+ is a state-of-the-art technology that enables a stable culture environment for embryos. Temperature is tightly regulated by direct heat contact and air is continuously purified through a HEPA/VOC filter. An integrated gas mixer allows the implementation of reduced oxygen conditions easily and economically. Small incubation chambers allow rapid recovery of culture conditions after door opening.

Constant time-lapse monitoring

EmbryoScope+ acquires images of all embryos in multiple focal planes. EmbryoScope+ uses high-quality Hoffman modulation contrast optics and acquire images of each individual embryo separately. This results in supreme image quality which allows observation of key morphological features. The image acquisition has been thoroughly validated to ensure safety in terms of both light wavelength and total energy exposure. Image data handling has been carefully considered to minimise data storage requirements while maintaining optimum image quality. This ensures seamless video playback.

Time-lapse culture and evaluation improve IVF success

• Improved implantation rate
Time-lapse improves your chances of transferring a viable embryo, resulting in increased clinical outcome.1-11

• Reduced pregnancy loss
Selecting the most viable embryo for implantation also means reducing the percentage of pregnancies lost or aborted.2,11

• Shorter time to pregnancy
Improving the clinical pregnancy rate while decreasing pregnancy losses effectively shortens the overall time to pregnancy.

Improved implantation rate

 

 

Reduced pregnancy loss

 

Improved pregnancy rate

 

Supportive software

Time-lapse analysis of embryo development is the key to improved evaluation. Data generated from EmbryoScope+ is analysed using the flexible EmbryoViewer software which allows viewing and analysis of embryos.

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The use of time-lapse significantly improves live birth rates and reduced early pregnancy loss rates

In a recent meta-analysis, eligible randomised controlled trials, which compare culture and evaluation using time-lapse systems with traditional embryo incubation and evaluation, were analysed to assess the effect of time-lapse.1

1 Pribenszky et al: Reprod Biomed Online (2017) 35(5): 511-520

Recently, the meta-analysis has been updated to include subsequently published randomised controlled studies in which time-lapse was used as a full system and live birth data was reported. This new meta-analysis strengthen the evidence of increased live births with the use of time-lapse systems on an intention to treat basis (n=1945, OR: 1.56, CI: 1.30-1.88, p<0.001)2

Importantly, the early pregnancy loss rate was significantly reduced with the application of time-lapse technology (relative reduction: 28%).

2 Pribenszky et al: Reprod Biomed Online (2018) 36(3): 290-292

Improved workflow with ES server

When introducing EmbryoScope+ to your IVF laboratory, you are guaranteed a digital transformation in the workflow. With the ES server, you can access the time-lapse data from all connected EmbryoScope+ incubators. Moreover, it is possible to view the data from multiple EmbryoViewer workstations. These can be placed in the IVF laboratory or in your office, and you can even access the data stored on the server from another clinic or another remote location using a secure connection. This enables you and your colleagues to view, annotate and select embryos with geographical flexibility.

Electronic Medical Record integration

EmbryoScope+ can be integrated with all compatible EMR systems.

EmbryoSlide+

• 16 embryos/dish, 15 dishes/incubator
• Barcode labelling
• 2 x 8 embryos distinct loading areas
• 2 x 180µl medium
• 1.6 mL oil
• 4 flushing / rinsing wells
• Individually numbered wells

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As the first clinic in the world to introduce time-lapse technology for all patients in 2010, we have seen an improvement in implantation rates while reducing multiple pregnancy rates by way of more single embryo transfer. We use EmbryoScope+ routinely for all our patients. We have the same great result as with EmbryoScope, with the added benefit of higher patient and embryo capacity as well as space savings in the lab.

Medical Director John Kirk, Maigaard Fertility Clinic

Download white paper

How can you benefit from time-lapse in IVF?

Dr. Markus Montag has written a white paper where he discusses the clinically proven results with time-lapse, as well as how time-lapse can improve the workflow in the lab and facilitate communication. 

Download white paper

Time-lapse & PGT - Better together

Many clinics have seen the benefit of making time-lapse a standard of care for their patients. The same is true for Preimplantation Genetic Testing (PGT). The fact that there are two such widely implemented techniques has created some questions about which new technology will offer the best treatment options for improving clinical outcome. In this webinar Dr. Tine Qvistgaard Kajhøj shows how time-lapse and PGT can be used together to offer the best overall possibility for improving outcomes and clinical workflow.

Watch webinar

EmbryoScope, the world’s most used

EmbryoScope time-lapse system continues to offer safe embryo management through a platform of products and services.

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Advanced software for improved embryo evaluation

EmbryoViewer software makes it possible to implement time-lapse-based embryo analysis with Guided Annotation and KIDScore decision support tools.

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Primo Vision EVO+, a modular time-lapse solution

By using existing incubators, you maintain your clinic’s trusted culture environment.

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References

1. Aguilar, J. et al., (2014), Reprod Biomed Online 28(4): 475-84.
2. Barrie, A. et al., (2016), Hum Fertil (Camb): 1-7.
3. Campbell, A. et al., (2013), Reprod Biomed Online 27(2): 140-6.
4. Basile, N., et al., (2015), Hum Reprod 30(2): 276-83.
5. Azzarello, A. et al., (2012), Hum Reprod 27(9): 2649-57.
6. Chamayou, S. et al., (2013), J Assist Reprod Genet 30(5): 703-10.
7. Dal Canto, M. et al., (2012), Reprod Biomed Online 25(5): 474-80.
8. Desai, N., et al., (2014),  Reprod Biol Endocrinol 12: 54.
9. Goodman, L.R. et al., (2016), Fertil Steril 105(2): 275-85 e10.
10. Meseguer, M. et al., (2012) Fertil Steril 98(6): 1481-9 e10.
11. Rubio, I. et al., (2014), Fertil Steril 102(5): 1287-1294 e5. 

How to use this product

Tech notes
EmbryoScope+ time-lapse system

Tech notes

Technote Preparation of EmbryoSlide+ culture dishes

Tech notes
EmbryoScope+ time-lapse system

Tech notes

Technote pH validation of culture medium in the EmbryoScope+

Tech notes
EmbryoScope+ time-lapse system

Tech notes

Technote Guided Annotation - daily workflow

Additional documents

Tech notes
EmbryoScope+ time-lapse system

Tech notes

Technote Guided Annotation - setting up

This technote describes how the Guided Annotation tool is set up in a completely customisable way to support the needs and strategies of your clinical workflow. This tool is designed to support the busy workdays in the laboratory and guides you from variable to the next in an annotation strategy and by automatically forwarding the embryo images to estimated timings of events. Guided Annotation in synergy with KIDScore models otpimally supports your consitent embryo assessment process.

Tech notes
EmbryoScope+ time-lapse system

Tech notes

Technote KIDScore D3 Basic

This technote describes the KIDScore D3 Basic, which is a model based on the morphokinetic traits associated with the implantation potential of embryos transferred on day 3. The model is designed to help clincs avoid transferring embryos with low implantation potential.

Tech notes
EmbryoScope+ time-lapse system

Tech notes

Technote KIDScore D5 decision support tool

This technote describes the KIDScore D5, which is a model based on morphology and morphokinetic traits associated with the implantation potential of embryos transferred on day 5. The model is designed to help clincs avoid transferring embryos with low implantation potential.

Tech notes
EmbryoScope+ time-lapse system

Tech notes

Technote - Consistent annotation for better evaluation - a guide on definitions for morphokitetics

This technote describes the definitions of variables most commonly used in embryo assessment with time-lapse. These definitions will help you attain consistent annotations and thereby objective evaluations in your clinic and further streamline the understanding of embryo deelopmental events within the clinic and beyond the clinic.

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