Genomics

Read up on studies

  • STAR trial: VeriSeq™ PGS

    The STAR trial: A randomised controlled trial (RCT) comparing pregnancy rates following VeriSeq™ PGS versus standard morphology for elective single embryo transfer (eSET).

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  • Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos

    Fiorentino et al., (2014) performed a validation of the VeriSeq PGS Solution to investigate its applicability to PGT-A. Karyotypically defined chromosomally abnormal single cells and whole-genome amplified products, previously analysed by array-CGH, selected from 68 clinical PGT-A cycles with embryos biopsied at cleavage stage. NGS specificity for aneuploid embryo call was 100% with a sensitivity of 100%. Fiorentino concluded that this product demonstrated a robust methodology ready for clinical applications in reproductive medicine, which potential advantages of reduced costs and enhanced precision.

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Increase my knowledge

  • Webinar: 'Genomics in Assisted Reproduction'

    The use of genomics has the potential to further transform assisted reproduction. In this recorded webinar we discuss the latest technologies that have potential applications in IVF. Listen to our expert speakers who will share their experience of current and future trends.

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  • Webinar: 'Current and Future Trends in PGT-A'

    In this recorded webinar, we will get insights from experts in the field of PGT-A in assisted reproduction. Our presenters will share retrospective data from PGT-A in highly successful programs, synergistic technologies to improve outcomes, and the future applications currently being investigated in research programs.

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  • Webinar: 'Utilising Genomics in IVF: From Carrier Screening to Karyomapping'

    The use of genomics in assisted reproduction has transformed IVF around the world. In this recorded webinar, you will join us for a rediscovery of Karyomapping PGT-M technology, including the ability to solve challenging cases, and an overview of the pivotal role of the clinician and genetic counsellor. 

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  • Webinar: 'PGT-M; Karyomapping uncovered'

    In this recorded version, you will join us for a rediscovery of Karyomapping PGT-M technology, including challenging cases solved and the concurrent detection of aneuploidies. Gain an understanding of the journey from a genetic counsellor’s perspective and discover the benefits of the comprehensive PGT-M solution.

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  • PGT-A and mosaicism - the good, the bad and the ugly

    Dr. Gary Harton is well known in the reproductive genetics field, where he has spent his entire career. In this blog post he will take you through the basics, the history, the advantages, the debates and what is yet to be determined when it comes to preimplantation genetic testing in assisted reproduction. 

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  • Webinar:'Current and future trends in PGT-A - incorporating PGT-A into the IVF journey'

    In this recorded webinar, Prof Alan Handyside reviews evidence for the effectiveness of PGT-A as an additional tool for embryo selection to improve clinical outcomes, particularly for single embryo transfers. Prof Handyside also considers how to implement PGT-A successfully and reviews prospects for non-invasive testing for aneuploidy (niPGT-A) using spent culture medium.

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  • Webinar:'Time-lapse and PGS – better together' 

    In this recorded version of a live webinar Dr. Tine Qvistgaard Kajhøj will discuss how PGS and time-lapse technology can be used together to offer the best overall possibility for improving outcomes and clinical workflow.

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  • Using PGS and time-lapse in synergy will enhance your decision making

    Picking out the embryo(s) most likely to be viable is the goal of any embryo selection process. Both time-lapse and preimplantation genetic screening (PGS) are well established methods for enhancing the chance of transferring a viable embryo. This blog post describes how using them together can enhance your decision making.

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  • Considerations when introducing PGS in your IVF clinic

    PGS aims to detect numerical and/or structural chromosomal disorders of the developing embryo. This white paper will guide you through the most important topics to consider when introducing PGS in your IVF laboratory.

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  • Time-lapse technology in a PGS world – is there room for both?

    Time-lapse and PGS are two ways of selecting embryos for transfer and cryopreservation. In this presentation from ESHRE 2016, Prof. Simon Fishel from CARE Fertility will present how these methods can complement each other.