FreezeKit™ & ThawKit™ Cleave
The new generation of slow freezing – optimised composition, convenient protocol and high survival rate.
Description MOPS buffered media.
Application For use in sequence after equilibration at room temperature and ambient atmosphere.
Storage Store dark at +2 to +8°C.
- Purpose: For freezing of pronuclear oocytes and cleavage stage embryos.
- Disclaimer: This product is not cleared for sale in US.
- Purpose: For thawing of frozen pronuclear oocytes and cleavage stage embryos.
- Disclaimer: This product is not cleared for sale in US.
- Purpose: For freezing of pronuclear (2PN) and cleavage-stage embryos.
- Disclaimer: Only for sale in the US.
New media composition
FreezeKit Cleave* and ThawKit Cleave* have been developed for freezing and thawing of pronuclear oocytes and cleavage stage embryos.
*US only: For freezing and thawing of pronuclear (2PN) and cleavage stage embryos.
Time-saving and convenient
FreezeKit Cleave and ThawKit Cleave make the whole slow freezing procedure faster and more convenient. With fewer steps compared to the current protocol they save time, reduce operator variability and simplify the training process.
Most importantly, embryos are exposed to less stress with the fewer steps and shorter handling times.
Significantly higher blastomere survival
Two clinics in Sweden made a pre-clinical, randomised comparison of FreezeKit Cleave and ThawKit Cleave with an existing commercial product for freezing of cleavage-stage embryos.
The primary endpoint was blastomere survival rate. A statistically significant difference in blastomere survival was seen between the two methods.
Does slowfreezing still have a role in cryopreservation in assisted reproduction?
Read guest blogger professor David Edgar's blog post about slow freezing and its role in cryopreservation.
Read blog post
How to use this product
Additional documents
Package inserts
Package insert ThawKit Cleave
Package inserts
Package insert FreezeKit Cleave US
Package inserts
Package insert ThawKit Cleave US
Short protocols
Short protocols - Cryo preservation Cleavage stage embryos
This short protocol describes how to slow-freeze zygotes and cleavage stage embryos using FreezeKit™ & ThawKit™ Cleave.
Scientific summaries
New formulations of slowfreezing solutions for cleavage stage embryos result in outcomes similar to after vitrification
A study by Fang et al, found that FreezeKit Cleave and ThawKit Cleave significantly improved survival rates, clinical pregnancy rates and implantation rates. In fact, a survival rate of above 90% using the new formulations of solutions is very similar to that obtained after vitrification.
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