Facilitating denudation prior to ICSI procedures.

Description Physiological salt buffer containing hyaluronidase and human serum albumin.

Purpose Medium for removal of cumulus cells.

Application For use after dilution. See product insert.

Storage Store dark at +2 to +8°C

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5 x 0.1 mL
  • Description: Containing gentamicin

Facilitating denudation

To be able to reach the oocyte and fulfill the mission of fertilisation, the spermatozoa release the enzyme hyaluronidase to make their way through the cumulus mass. In vitro, if ICSI is used as a fertilisation method, the cumulus cells must be removed by the embryologist. The same enzyme released by the spermatozoa is used.

When oocytes are placed in diluted HYASE-10X the cumulus mass is dispersed in a few seconds and the cells can easily be removed with a denudation pipette.

The concentration of hyaluronidase in HYASE-10X is 800 IU/mL

How we secure performance

Before releasing HYASE-10X, we simulate your work and your reality. Every batch of HYASE-10X is tested using Vitrolife’s proprietary MEA method. By placing mouse cumulus complexes in HYASE-10X for a set time, it is possible to check lot-to-lot consistency and enzyme activity by comparing with reference material.

Support Documents

Documents Language


Package inserts


Package insert HYASE-10x 10176 - Multi-language

Document and Ref: REF 26284, version 02


Safety data sheets (SDS)



Document and Ref: Date Revised : 06/27/2023. Revision No : 6. Safety data sheet for HYASE-10X


Short protocols


G-Series™ ICSI procedure

Document and Ref: REF 19122. Version 02. Date of issue 220923. This short protocol describes how to perform ICSI using ICSI™, HYASE™-10x, OVOIL™ and G-Series medium G-MOPS™ PLUS .


Short protocols


Gx-Series™ ICSI procedure

Document and Ref: REF 19179. Version 1. Date of issue 220923 This short protocol describes how to perform ICSI using ICSI™, HYASE™-10x, OVOIL™ and Gx-Series medium Gx-MOPS™ PLUS and Gx-TL™

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