EmbryoGlue®
Implantation promoting medium for increased take-home baby rate.
Description Bicarbonate buffered medium containing hyaluronan and recombinant human albumin.
Purpose Medium for embryo transfer.
Application For use after pre-equilibration at +37ºC and 6 % CO2.
Storage Store dark at +2 to +8°C
Optimised transfer
Embryo transfer is one of the most sensitive and critical procedures in IVF treatment. EmbryoGlue is a medium developed exclusively for embryo transfer and the only existing product with a proven implantation-enhancing effect1.
EmbryoGlue has the basic composition of a rich blastocyst culture medium and contains a high concentration of hyaluronan and recombinant human albumin. It is uniquely developed to mimic the conditions in the female uterus in order to help embryos implant after transfer.
REF: 1. Bontekoe et al. Adherence compounds in embryo transfer media for assisted reproductive technologies (Review). The Cochrane Collaboration 2014. Published by John Wiley & Sons, Ltd.
Proven effect
When EmbryoGlue was used for embryo transfer the clinical pregnancy rate was significantly increased from 41% to 49% compared to when a conventional culture medium with low or no hyaluronan was used.
The meta-analysis of the 13 publications included in the Cochrane review article included more than 3200 patients. Importantly, the analysis did not show any increase in miscarriages or other adverse events. The conclusion by the Cochrane authors was that "a clear positive effect (of having high concentrations of hyaluronan in the transfer medium) was identified".
How does is work?
EmbryoGlue contains a high concentration of implantation promoting hyaluronan together with all nutrients and energy sources needed for an optimal embryo development.
Watch this movie where it is explained how EmbryoGlue works and how it supports implantation of the embryo.
The most documented implantation promoting medium
Since the introduction of EmbryoGlue in 2003, several studies have been published regarding its effect. In this comprehensive booklet, Dr Ann-Helene Jakobsson has summarised a significant number of studies, looking at the benefit of EmbryoGlue when used for different patient groups.
Download ‘EmbryoGlue- summaries of selected studies'
The benefit of extended exposure to EmbryoGlue when transferring cryopreserved blastocysts
New data supporting treatment benefits with EmbryoGlue is being presented at ASRM. The study is looking at the benefit of extended exposure to EmbryoGlue when transferring cryopreserved blastocysts. Listen to Dr. Oscar Perez, lab director of Dallas Fertility Center, explaining the research and result.
New study evaluating the benefit of EmbryoGlue in PCOS patients
A study by Sayali Kandari, MS PhD, Cellsure Biotech And Research Centre, Mumbai, India, has evaluated the benefit of EmbryoGlue in PCOS patients. The use of EmbryoGlue for time-lapse selected sET in PCOS shows significant increase in implantation and live birth rates with lower miscarriage rates compared with conventional embryo transfer medium.
EmbryoGlue improves the chance of having a baby
See this movie where Laboratory Director Basak Balaban from American Hospital of Istanbul in Turkey explains how using EmbryoGlue for transfer can increase the chance to have a baby.
Implantation promoting medium with documented success
EmbryoGlue is exclusively developed to mimic the conditions in the female uterus in order to help embryos implant after transfer.
In this white paper it is further described what makes EmbryoGlue increase take-home baby rates in IVF
Download white paper
Optimise all the way with G-Series
Ensure optimal conditions before, during and after culture by using the whole G-Series™. All G-Series media share the same basic composition to secure viability and implantation potential. Osmolality, pH and supporting compounds are all kept constant. This foundation prevents intracellular stresses as the embryos progress through the IVF process.
Support Documents
Documents Language
Package inserts
English
Package insert EmbryoGlue REF 10085
Package inserts
English
Package insert EmbryoGlue REF 10168
Short protocols
English
Short protocol - Embryo transfer
This short protocol describes how to perform embryo transfer using EmbryoGlue®.
Product manuals
English
Manual G-Series. International
This manual describes how to use all media in the G-Series: G-RINSE, G-MOPS, G-GAMETE, G-IVF, G-1, G-2, G-TL, G-PGD, HSA-solution, G-MM, ICSI, HYASEx-10x, OVOIL , SpermGrad and EmbryoGlue.
Short protocols
English
Short protocols - Embryo transfer
This short protocol describes how to perform embryo transfer using EmbryoGlue® 5x1.5 ml
Product manuals
English
Manual G-Series. For US
This manual describes how to use all media in the G-Series: G-RINSE, G-MOPS, G-GAMETE, G-IVF, G-1, G-2, G-TL, G-PGD, HSA-solution, G-MM, ICSI, HYASEx-10x, OVOIL, SpermGrad and EmbryoGlue
Scientific summaries
English
EmbryoGlue improves pregnancy and implantation rates. Results from a meta-analysis on almost 10,000 embryo transfers
A meta-analysis of Japanese studies, including almost 10,000 cycles shows that EmbryoGlue improves implantation resulting in increased pregnancy rates confirming findings from the Cochrane reports.
Safety data sheets (SDS)
English
SDS EmbryoGlue
Safety data sheet for EmbryoGlue
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