Learn more about how EmbryoScope can help with your IVF treatmentLearn more
Time-lapse technology reduces observational time restrictions and stress to embryos during culture and assessment. With time-lapse you can enjoy undisturbed culture and continuous image acquisition and improve your selection process through a more objective analysis.
The desire to observe embryos regularly in order to make accurate assessments, while minimising disturbance to avoid stressing them, has been a long-standing dilemma. Time-lapse technology solves this problem by giving you continuous observation in an undisturbed culture. Once taken, acquired images can be played as a film that can be analysed at the clinic and remotely. Without time-lapse, embryos must be taken out of the incubator to be assessed, exposing them to unnecessary stress and fluctuations.
Based on more than a decade of experience in optimal design and a specialised knowledge of all processes involved when incubating and monitoring embryos, EmbryoScope time-lapse system continues to offer safe embryo management through a platform of products and services.
The integrated design of the EmbryoScope time-lapse incubator has been developed to ensure stable incubation while automatically acquiring images of the developing embryos at defined intervals. This information is transferred to the ES server which can then be accessed from conveniently placed EmbryoViewer stations.
EmbryoScope is a state-of-the-art technology that enables a stable culture environment for embryos. Temperature is tightly regulated by direct heat contact and air is continuously purified through a HEPA/VOC filter. An integrated gas mixer allows the implementation of reduced oxygen conditions easily and economically. Small incubation chambers allow rapid recovery of culture conditions after door opening.
EmbryoScope acquires images of all embryos in multiple focal planes. EmbryoScope uses high-quality Hoffman modulation contrast optics and acquire images of each individual embryo separately. This results in supreme image quality which allows observation of key morphological features. The image acquisition has been thoroughly validated to ensure safety in terms of both light wavelength and total energy exposure. Image data handling has been carefully considered to minimise data storage requirements while maintaining optimum image quality. This ensures seamless video playback.
• Improved implantation rate
Time-lapse improves your chances of transferring a viable embryo, resulting in increased clinical outcome.1-11
• Reduced pregnancy loss
Selecting the most viable embryo for implantation also means reducing the percentage of pregnancies lost or aborted.2,11
• Shorter time to pregnancy
Improving the clinical pregnancy rate while decreasing pregnancy losses effectively shortens the overall time to pregnancy.
Time-lapse analysis of embryo development is the key to improved evaluation. Data generated from EmbryoScope+ is analysed using the flexible EmbryoViewer software which allows viewing and analysis of embryos.Learn more
In a recent meta-analysis, eligible randomised controlled trials, which compare culture and evaluation using time-lapse systems with traditional embryo incubation and evaluation, were analysed to assess the effect of time-lapse.1
1 Pribenszky et al: Reprod Biomed Online (2017) 35(5): 511-520
Recently, the meta-analysis has been updated to include subsequently published randomised controlled studies in which time-lapse was used as a full system and live birth data was reported. This new meta-analysis strengthen the evidence of increased live births with the use of time-lapse systems on an intention to treat basis (n=1945, OR: 1.56, CI: 1.30-1.88, p<0.001)2
Importantly, the early pregnancy loss rate was significantly reduced with the application of time-lapse technology (relative reduction: 28%).
2 Pribenszky et al: Reprod Biomed Online (2018) 36(3): 290-292
When introducing EmbryoScope to your IVF laboratory, you are guaranteed a digital transformation in the workflow. With the ES server, you can access the time-lapse data from all connected EmbryoScope incubators. Moreover, it is possible to view the data from multiple EmbryoViewer workstations. These can be placed in the IVF laboratory or in your office, and you can even access the data stored on the server from another clinic or another remote location using a secure connection. This enables you and your colleagues to view, annotate and select embryos with geographical flexibility.
EmbryoScope can be integrated with all compatible EMR systems.
• 12 embryos/dish, 6 dishes/incubator
• 12x25µl medium
• 4 flushing / rinsing wells
• Individually numbered wells
• Lid ensures minimal evaporation
• Handling fin for safe transfer between workplaces
We have seen the the number of single embryo transfer double since the introduction of time-lapse technology, due to increased information on embryo development.
Jenny Cloherty, Lab Director, Galway Fertility Clinic, Ireland
Dr. Markus Montag has written a white paper where he discusses the clinically proven results with time-lapse, as well as how time-lapse can improve the workflow in the lab and facilitate communication.
Many clinics have seen the benefit of making time-lapse a standard of care for their patients. The same is true for Preimplantation Genetic Testing (PGT). The fact that there are two such widely implemented techniques has created some questions about which new technology will offer the best treatment options for improving clinical outcome. In this webinar Dr. Tine Qvistgaard Kajhøj shows how time-lapse and PGT can be used together to offer the best overall possibility for improving outcomes and clinical workflow.Watch webinar
EmbryoScope+ is designed to meet the needs of clinics wishing to implement time-lapse as a standard of care to more of their patients.Learn more
EmbryoViewer software makes it possible to implement time-lapse-based embryo analysis with Guided Annotation and KIDScore decision support tools.Learn more
By using existing incubators, you maintain your clinic’s trusted culture environment.Learn more
1. Aguilar, J. et al., (2014), Reprod Biomed Online 28(4): 475-84.
2. Barrie, A. et al., (2016), Hum Fertil (Camb): 1-7.
3. Campbell, A. et al., (2013), Reprod Biomed Online 27(2): 140-6.
4. Basile, N., et al., (2015), Hum Reprod 30(2): 276-83.
5. Azzarello, A. et al., (2012), Hum Reprod 27(9): 2649-57.
6. Chamayou, S. et al., (2013), J Assist Reprod Genet 30(5): 703-10.
7. Dal Canto, M. et al., (2012), Reprod Biomed Online 25(5): 474-80.
8. Desai, N., et al., (2014), Reprod Biol Endocrinol 12: 54.
9. Goodman, L.R. et al., (2016), Fertil Steril 105(2): 275-85 e10.
10. Meseguer, M. et al., (2012) Fertil Steril 98(6): 1481-9 e10.
11. Rubio, I. et al., (2014), Fertil Steril 102(5): 1287-1294 e5.
Technote Minimal evaporation using non-humidified incubation conditions
This technote shows that correct use of the EmbryoSlide culture dish with oil overlay and lid does not lead to significant evaporation in the non-humidified environment of the EmbryoScope time-lapse incubator.
Technote Incubation temperature of the EmbryoScope time-lapse incubator
This technote shows that core temperature measurements of the slide arm is a valid indirect measure of temperature of media in the EmbryoSlide culture dish mocrowell. External validation of temperature control in the EmbryoScope time-lapse incubator is accomplished by measuring core temperature in the EmbryoSlide culture dish arm using a YSI probe.
Technote Safety of incubation in the EmbryoScope time-lapse system
This technote gives an overview of the safety features and validation for human embryo culture in the EmbryScope time-lapse system.
Technote Preparation of EmbryoScope culture dish
Technote Preparation of EmbryoScope culture dish
Technote - Additional notes for EmbryoSlide culture dish preparation
Additional technote on proper preparation of the EmbryoSlide dish to ensure optimum image acquisition and culture conditions