Evaluation tools

Decision support tools scoring embryos according to their statistical viability by applying a number of criteria to the embryos.

Purpose For embryo evaluation.

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16536 iDAScore
  • Description: Fully automated AI-based decision support tool for day 5 culture.
  • Purpose: AI Algorithm with automatic scoring of embryos, to improve workflow.
  • Disclaimer: Not for sale in US
16531 KIDScore D3
  • Description: Embryo decision support tool software for Day 3 selection. KIDScore is a trademark of Vitrolife Group.
16532 KIDScore D5
  • Description: Upgrade for existing KIDScore D3. KIDScore is a trademark of Vitrolife Group.
  • Disclaimer: Not for sale in US
16533 KIDScore D3 + D5
  • Description: Embryo decision support tool software for Day 3 and Day 5 full package. KIDScore is a trademark of Vitrolife Group.
  • Disclaimer: Not for sale in US

iDAScore

AI based automated analysis

Automated analysis at your fingertips

iDAScore makes use of deep learning to provide fully automated analyses of developing embryos. Now you can get an objective ranking based on the likelihood of implantation of each of a patient´s embryos at once - at the touch of a button. The future of embryo evaluation begins here.

Simplicity in action

iDAScore is simple and intuitive, with no manual export or import of images or videos required.

Get a glimpse of the iDAScore interface by watching the trailer.

AI scoring is not affected by

 

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Improved evaluation

Traditional embryo evaluation methods are prone to subjectivity and external factors. Experience level, time constraints and lab staffing may all affect evaluation of embryos. It has been shown that an embryologist may score the same blastocyst differently on separate occasions. 1,2 iDAScore objectively “compares” a given embryo with other embryos that have similar development patterns, and generates a score correlating with the likelihood of implantation.

How iDAScore works

 

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Consistent

Consistent approach to embryo
evaluation. Day to day differences
in staffing, or introduction of new
embryologists will not affect the
way embryos are scored.

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Objective

Objectively analyses the full embryo
development sequence, without
inherent human bias.

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Fully automated

Analyses time-lapse sequences
continuously, without the need
for manual processing of data or
videos.

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Reliable

Provides a reliable ranking of a
patient’s cohort of embryos. Embryos
can be evaluated adjunctively with
EmbryoViewer software or other well
established scoring schemes.

 

“With a clear easy to use interface iDAScore makes choosing between multiple blastocysts an easier job. The score matches well with the decisions of experienced embryologists, and KIDScore D5. We think that in time, iDAScore will become an invaluable tool in helping to make our day to day clinical decisions. In addition, we are hoping to use it to assess already frozen embryos which were cultured in the EmbryoScope+. ”

-Alan Birks, Senior Clinical Embryologist
Manchester Fertility, UK

 

"iDAScore provides an impressive ranking of embryos. We see that the correlation with implantation, shows the same positive trend as with the KIDScore D5 decision support tool. This could be a game changer in the future of embryo evaluation, as we gain more trust in using AI for embryo evaluation.”

-Tony Price, Embryology Manager
Wessex Fertility, UK

 

“iDAScore is an ideal tool for providing a fast prioritization of embryos for further examination. This is especially useful for guiding new embryologists and helping them to evaluate embryos in a way that is more consistent with evaluation by senior staff with many years of experience.”

-Kirsten Simonson, Clinical embryologist
Maigaard fertility, Denmark

BUILDING ON THE POWER OF AI

iDAScore was trained on 115,000 full time-lapse sequences of embryos. Of these 14,644 were transferred 4,337 were Fetal Heart Beat positive. Data was from 18 clinics and included a wide range of ages as well as including both fresh and frozen transfers. Validation was performed by having hold out data sets that were not included in the training and were used for validation

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* KID Embryos: Embryos with Known Implantation Data

A robust algorithm

iDAScore was trained and validated on a large and diverse dataset, resulting in a robust AI model that generalises well to clinics whose data was not included in the training process. Automatic embryo scoring by AI shows convincing results for all provided subgroups of data and can be expected to generalise well to all clinics.

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To test how well the model generalises, a clinic hold out test* was performed3. Data from 18 clinics was used, where data from 1 clinic was excluded from training and the AUC* for the hold out clinic was calculated. Data from the 12 clinics contributing the most data is shown. AUC* when considering all embryos exceeded 0.9 for the hold out clinics.

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The algorithm was tested on data across age groups3. We see that iDAScore performs equally well at ranking all embryos in all of the age groups tested. AUC* in the 40+ category is slightly lower, likely due to patient factors.

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Different clinics may have different distributions of the proportion of IVF or ICSI insemination. In this study3, all data with associated labelling of insemination type was analysed. This shows equal performance regardless of insemination method.

*AUC: AUC is a measure of the ability of the algorithm to sort embryos based on their likelihood of implantation. An AUC of 1 means that the prediction is always correct whereas an AUC of 0.5 corresponds to random predictions.

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Time of culture was also shown to provide similar results3. Data was subdivided into 4 subgroups, 1<15 hpi, 115-117 hpi, 117-119 hpi and >119 hpi to get a more detailed view. This confirms that clinics have a flexible time window to perform analysis.

*Hold out test: A hold out test is a method to assure that the model is based on general and not case-specific patterns. In a hold out test the data set is split into a training set and a validation set to be able to validate the model on independent data. This is done repeatedly until all subsets of data have been used for validation.

iDAScore® - the future of AI-based embryo evaluation

Are you interested in learning more about how artificial intelligence can be used in IVF? Read this blog post by Dr. Tine Qvistgaard Kajhøj where she takes you through the evolution of Vitrolife’s AI-based tools for IVF. 

Read blog post

 
Presentations from our scientific symposiums:

'The Future is here: Starting the journey with AI based embryo evaluation' at IVF WW Congress 2021 &
'AI based embryo evaluation: Empower your decisions' at ESHRE 2020

The Future is here: Starting the journey with AI based embryo evaluation

Presented by:

  • Simon Cooke, Scientific Director of IVF Australia
  • Jens Rimestad, Deep Learning Specialist at Vitrolife
  • Anthony Price, Embryology Manager at Wessex Fertilty Clinic

From AI to Bedside

Presented by Dr. Aengus Tran, MD, Harrison.AI (Sydney, Australia).

iDAScore – development of robust AI based embryo evaluation

Presented by Jens Rimestad, Deep Learning Specialist (Aarhus, Denmark).

Guided annotation

Data analysis

Advanced software

With EmbryoViewer software, you can review, annotate and compare development of selected embryos from data acquired by the EmbryoScope, EmbryoScope+, EmbryoScope 8 and EmbryoScope Flex. The same EmbryoViewer software can be used for the four types of incubators. The incubators’ running conditions are automatically stored with the patient data and can be observed on the EmbryoViewer software for quality assurance.

See what you've been missing

With EmbryoViewer software, you can achieve improved selection, or de-selection, of embryos by a combination of discovering both morphological and morphokinetic parameters. Important parameters such as the dynamic morphology, critical cleavage patterns and morphokinetics can only be observed with time-lapse technology.

Traditional embryo assessment has been reported to miss more than 70% of embryo multinucleation while more than 20% of embryos have been reported to go through an abnormal cleavage pattern. Such patterns can only be precisely determined by the use of
time-lapse.1-4

Get the most information to make the best choice

Traditional evaluation of embryos limits the amount of information about embryo development. Using time-lapse analysis, you can detect previously unseen embryo development patterns and events which have been correlated to clinical outcome. With EmbryoViewer software and Guided Annotation, you can analyse high quality videos of embryo development and easily register the information you need about each embryo to make evaluation efficient.

Intuitive annotation tools

With EmbryoViewer software, you can annotate cell division events, providing an easy overview of observations in developmental stages.

Improved basis for embryo selection

Use Guided Annotation in the EmbryoViewer software to efficiently get the parameters you need for embryo evaluation. Designed to provide a simplified annotation workflow.

KIDScore for efficient evaluation support

KIDScore™ decision support tools* assigns an objective score to each embryo. The scores reflect implantation potential and provide consistent and effective support for embryo evaluation. With Guided Annotation and KIDScore decision support tools you can customise to fit the workflow you like with the level of automatisation you prefer.

*KIDScore D5 has not received 510(k) clearance

Add intelligence with Guided Annotation

Guided Annotation is an added, optional tool in the EmbryoViewer software designed to provide a simplified annotation workflow. Based on artificial intelligence, Guided Annotation provides a perfect balance of control, accuracy and efficiency – ensuring fast, precise and consistent analysis of embryo development based on your needs for information before embryo selection.

Ensure consistent evaluation of embryos with Guided Annotation

With the extensive amount of image information acquired by the EmbryoScope time-lapse system, every stage of development of each embryo can be observed. Guided Annotation ensures that you collect exactly the amount and type of embryo development information that is necessary for you to evaluate which embryos are most suitable for transfer and/or freezing.

By implementing intelligent software tools and artificial intelligence, Guided Annotation makes embryo annotation fast, efficient and precise and allows you to have complete control of the level of automatisation. A confidence estimate allows you to automate annotations that have a high confidence level and prioritise validation of annotations with low confidence.

Eased workflow, efficiency and consistency

The Guided Annotation tool uses image analysis to guide you to likely timings for developmental events like division timings, morphology assessment and PN check. Simply validate or score the event by a single keyboard click.

Simplicity

Based on the annotation strategy, Guided Annotation automatically prompts you to annotate the selected variables. A continuous overview of the process is provided.

Efficiency

An efficient workflow is easily achieved by utilising customised annotation strategies in combination with the intuitive and ergonomics friendly keyboard shortcuts.

Consistency

Define an annotation strategy, or determine which predefined annotation strategy to use, and collect consistent and valuable information by all staff.

KIDScore

Decision support

Guided Annotation and KIDScore

Guided Annotation in synergy with KIDScore optimally supports your consistent embryo evaluation process.

Benefits of KIDScore

• Improves the decision-making process
• Enhances consistency
• Helps you obtain better results

  

KIDScore™ decision support tool

KIDScore assigns an objective score to each embryo. The scores reflect implantation potential and provide consistent and effective support for embryo selection.

KIDScore for transfer on Day 3 or Day 5

The KIDScore decision support tool is developed by analysing the world’s largest database of embryo development with known clinical outcome. The models are developed by analysing how embryo morphokinetics, cleavage patterns and morphology correlates with implantation outcome after transfer.

Principles of KIDScore D3

Enjoy immediate benefits of time-lapse-based embryo analysis

• Improved consistency of evaluation and lower interobserver variability5
• Uses ‘easy-to-annotate’ variables
• Based on Known Implantation Data (KID) from the day of transfer
• A powerful tool when you have more embryos available than planned for transfer
• Designed to predict implantation

KIDScore D3

When to use it
• When deciding between embryos that reach expected stage on day 3
• When D3 SET is preferred

How does it work?
KIDScore D3 assigns a morphokinetic score from 1-5 to your annotated embryos. The score from 1-5 is a relative measure of the implantation potential of the embryo. The following variables need to be annotated in accordance with specific guidelines: PN assessment, PN fading, time (t) to 2, 3, 4, 5 and 8 cells.

KIDScore D3 & implantation data
The chart represents unselected embryos, embryos chosen for transfer, implanted embryos and embryos resulting in a live birth from cycles where known outcome data is available. The distribution of embryos across score groups is shown. This indicates that there is excellent concordance between the model and embryos with high implantation potential.

KIDScore D5

When to use it? 

• When more good quality blastocysts are available than are planned for transfer
• When deciding which embryos are suitable for biopsy or diagnosis

How does it work?

KIDScore D5* considers the morphology and the morphokinetic traits of an embryo. For each embryo the model calculates a continuous score from 1-9.9. The score reflects the statistical chance of implantation based on development information from the five-day culture period. The higher the score, the greater the statistical chance of implantation. Only a few annotations are required to obtain a score, which further improves the worfklow.

KIDScore D5 & implantation data
KIDScore D5 scores show an increased relative implantation with higher scores. The model is based on a large database of KID blastocysts originating from a wide range of IVF clinics.

*KIDScore D5 can only be used when culturing under reduced oxygen conditions

We have seen improved IVF outcomes since we introduced EmbryoScope time-lapse system in 2013. We owe it to our patients to use time-lapse - to give them the best possible result.

- Helen Hunter, principal embryologist, Department of Reproductive Medicine, Saint Mary's Hospital, Manchester, UK

 

How can you benefit from time-lapse in IVF?

Dr. Markus Montag has written a white paper where he discusses the clinically proven results with time-lapse, as well as how time-lapse can improve the workflow in the lab and facilitate communication. 

Download white paper

EmbryoScope+, making time-lapse standard of care

EmbryoScope+ is designed to meet the needs of clinics wishing to implement time-lapse as a standard of care to more of their patients.

Learn more

EmbryoScope 8 - optimal capacity to suit your clinics need

EmbryoScope 8 time-lapse system is designed to meet the needs of smaller clinics who want to enjoy the same great benefits of the EmbryoScope+ family of time-lapse systems.

Learn more

EmbryoScope Flex, ideal for mild stimulation & low responder patients

Expanding your possibilities to offer time-lapse as a standard of care to more patients.

Learn more

References

1. Ergin, E.G. et al., (2014), Fertil Steril 102(4): 1029-1033 e1.
2. Data on file.
3. Rubio, I. et al., (2012), Fertil Steril 98(6): 1458-63.
4. Zhan, Q. et al., (2016) PLoS One 11(12): e0166398. 
5. Sundvall, et al., (2013), Hum Reprod 28(12): 3215-21. 

How to use this product

Technotes
Evaluation tools

Technotes

Technote KIDScore D3 decision support tool

Product manuals
Evaluation tools

Product manuals

KIDScore D5 Appendix_ver 3 Greek

Product manuals
Evaluation tools

Product manuals

iDAScore User Manual_ver 1 Greek

Additional documents

Product manuals
Evaluation tools

Product manuals

KIDScore D3 Appendix_ver 2 Greek

Product manuals
Evaluation tools

Product manuals

KIDScore Decision Support Tool_User Manual_ver 4 Greek

Product manuals
Evaluation tools

Product manuals

Guided Annotation Quick Guide_ver 7.7 Greek

Product manuals
Evaluation tools

Product manuals

KIDScore Decision Support Tool_User Manual_ver 4 German

Product manuals
Evaluation tools

Product manuals

KIDScore D5 Appendix_ver 3 German

KIDScore D5 has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore D3 Appendix_ver 2 German

Product manuals
Evaluation tools

Product manuals

Guided Annotation Quick Guide_ver 7.7 German

Product manuals
Evaluation tools

Product manuals

iDAScore User Manual_ver 1 German

iDAScore has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore D5 Appendix_ver 3 French

KIDScore D5 has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore Decision Support Tool_User Manual_ver 4 French

Product manuals
Evaluation tools

Product manuals

iDAScore User Manual_ver 1 French

iDAScore has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore D3 Appendix_ver 2 French

Product manuals
Evaluation tools

Product manuals

Guided Annotation Quick Guide_ver 7.7 French

Product manuals
Evaluation tools

Product manuals

KIDScore D5 Appendix_ver 3 Estonian

KIDScore D5 has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore D3 Appendix_ver 2 Estonian

Product manuals
Evaluation tools

Product manuals

KIDScore Decision Support Tool_User Manual_ver 4 Estonian

Product manuals
Evaluation tools

Product manuals

Guided Annotation Quick Guide_ver 7.7 Estonian

Product manuals
Evaluation tools

Product manuals

iDAScore User Manual_ver 1 Estonian

iDAScore has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore D3 Appendix_ver 2 Danish

Product manuals
Evaluation tools

Product manuals

KIDScore Decision Support Tool_User Manual_ver 4 Danish

Product manuals
Evaluation tools

Product manuals

KIDScore D5 Appendix_ver 3 Danish

KIDScore D5 has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

iDAScore User Manual_ver 1 Danish

iDAScore has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

Guided Annotation Quick Guide_ver 7.7 Danish

Product manuals
Evaluation tools

Product manuals

KIDScore D5 Appendix_ver 3 Czech

KIDScore D5 has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore D3 Appendix_ver 2 Czech

Product manuals
Evaluation tools

Product manuals

iDAScore User Manual_ver 1 Czech

iDAScore has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

Guided Annotation Quick Guide_ver 7.7 Czech

Product manuals
Evaluation tools

Product manuals

KIDScore Decision Support Tool_User Manual_ver 4 Czech

Product manuals
Evaluation tools

Product manuals

KIDScore Decision Support Tool_User Manual_ver 4 Chinese (traditional)

Product manuals
Evaluation tools

Product manuals

KIDScore D5 Appendix_ver 3 Chinese (traditional)

KIDScore D5 has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore D3 Appendix_ver 2 Chinese (traditional)

Product manuals
Evaluation tools

Product manuals

Guided Annotation Quick Guide_ver 7.7 Chinese (traditional)

Product manuals
Evaluation tools

Product manuals

iDAScore User Manual_ver 1 Chinese (traditional)

iDAScore has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore D5 Appendix_ver 3 Chinese (Simplified)

Product manuals
Evaluation tools

Product manuals

KIDScore D3 Appendix_ver 2 Chinese (Simplified)

Product manuals
Evaluation tools

Product manuals

iDAScore User Manual_ver 1 Chinese (Simplified)

Product manuals
Evaluation tools

Product manuals

Guided Annotation Quick Guide_ver 7.7 Chinese (Simplified)

Technotes
Evaluation tools

Technotes

Technote Guidelines for blastocyst morphology grading with time-lapse

This technote describes the grading of blastocyst morphology with the use of time-lapse technology. This facalitates a more thorough evaluation because the complete course of development can be considered. A comprehensive impression of the blastocyst can be used as the basis for grading morphology, which should be utilised when grading ICM and TE and is neccessary when using KIDScore D5.

Technotes
Evaluation tools

Technotes

Technote - Consistent annotation for better evaluation - a guide on definitions for morphokitetics

This technote describes the definitions of variables most commonly used in embryo assessment with time-lapse. These definitions will help you attain consistent annotations and thereby objective evaluations in your clinic and further streamline the understanding of embryo developmental events within the clinic and beyond the clinic.

Technotes
Evaluation tools

Technotes

Technote Guided Annotation - setting up

This technote describes how the Guided Annotation tool is set up in a completely customidable way to support the needs and strategies of your clinical workflow. This tool is designed to support the busy workdays in the laboratory and guides you from variable to the next in an annotation strategy and by automatically forwarding the embryo images to estimated timings of events. Guided Annotation in synergy with KIDScore models optimally supports your consistent embryo assessment process.

Technotes
Evaluation tools

Technotes

Technote Guided Annotation - daily workflow

This technote is about the Guided Annotation tool, which is designed to support the busy workdays in the laboratory. The tool guides you from variable to the next in an annotation strategy and by automatically forwarding the embryo images to estimated timings of events. Guided Annotation in synergy with KIDScore models optimally supports your consistent embryo assessment process.

Product manuals
Evaluation tools

Product manuals

Guided Annotation Detailed Guidelines_ver 7.7 English

Product manuals
Evaluation tools

Product manuals

Guided Annotation Quick Guide_ver 7.7 English

Product manuals
Evaluation tools

Product manuals

iDAScore User Manual_ver 1 English

iDAScore has not received 510(k) clearance.

Product manuals
Evaluation tools

Product manuals

KIDScore D3 Appendix_ver 2 English

Product manuals
Evaluation tools

Product manuals

KIDScore Decision Support Tool_User Manual_ver 4 English

Product manuals
Evaluation tools

Product manuals

KIDScore D5 Appendix_ver 3 English

KIDScore D5 has not received 510(k) clearance.

Technotes
Evaluation tools

Technotes

Technote_KIDScore D5 decision support tool

This technote describes the KIDScore D5, which is a model based on morphology and morphokinetic traits associated with the implantation potential of embryos transferred on day 5. The model is designed to help clincs avoid transferring embryos with low implantation potential.

Technotes
Evaluation tools

Technotes

Technote Tracking individual outcome in EmbryoViewer software

This technote gives an overview of how to track individual transfer outcome in the EmbryoViewer software.

Technotes
Evaluation tools

Technotes

Technote Effect and prevalence of embryo developmental traits

This technote contains a summary of the prevalence and effect of developmental traits which can only be observed with time-lapse.

Technotes
Evaluation tools

Technotes

Technote Guidelines for getting started with models in Compare & Select

This technote gives you simple starting tips to make the most of your data when using morphokinetics to build a model customised for your clinic.

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